Chromosome Biology and Gene Expression

science stuff

A mechanistic understanding of the interconnected roles that chromosome structure, chromatin and gene expression play in cell identity and proliferation is critical to multiple areas in basic biology and biomedicine. With the advances in next generation sequencing (NGS) and proteomics technologies, these fundamental issues can now be probed at a breadth and depth unimaginable even ten years ago. Several research programs in the department address important issues in chromosome structure, duplication and gene expression in a variety of model systems exploiting both cutting-edge NGS and proteomics approaches as well as classical microbiological, genetic, and molecular methods.

Relevant Labs: Brow, Dvinge, Hull, Kiley, Lewis, Fox, Denu, Keck, Harrison, Sheets

David A. Brow

Credentials: RNA biology and gene expression in eukaryotes

Position title: Professor

Email: dabrow@wisc.edu

John M. Denu

Credentials: Mechanisms of chromatin dynamics, epigenetic, metabolism and signaling

Position title: Professor (also Epigenetics Theme Leader, Wisconsin Institute for Discovery)

Email: jmdenu@wisc.edu

Catherine A. Fox

Credentials: Conservation and diversity in mechanisms that control the inheritance and expression of eukaryotic chromosomes

Position title: Professor

Email: cfox@wisc.edu

Melissa M. Harrison

Credentials: Transcriptional regulation during development

Position title: Associate Professor

Email: mharrison3@wisc.edu

Christina M. Hull

Credentials: Human fungal pathogen development and pathogenesis

Position title: Professor (also Professor of Medical Microbiology & Immunology)

Email: cmhull@wisc.edu

James L. Keck

Credentials: Structural mechanisms of genome maintenance

Position title: Professor and Assoc. Dean for Basic Research Training

Email: jlkeck@wisc.edu

Peter W. Lewis

Credentials: Chromatin dynamics in cancer

Position title: Associate Professor

Email: peter.lewis@wisc.edu

Michael D. Sheets

Credentials: RNA regulation of cell fate and function

Position title: Professor

Email: mdsheets@wisc.edu