A mechanistic understanding of the interconnected roles that chromosome structure, chromatin and gene expression play in cell identity and proliferation is critical to multiple areas in basic biology and biomedicine. With the advances in next generation sequencing (NGS) and proteomics technologies, these fundamental issues can now be probed at a breadth and depth unimaginable even ten years ago. Several research programs in the department address important issues in chromosome structure, duplication and gene expression in a variety of model systems exploiting both cutting-edge NGS and proteomics approaches as well as classical microbiological, genetic, and molecular methods.
Relevant Labs: Brow, Campbell, Denu, Fox, Harrison, Hess, Hull, Keck, Kiley, Lewis, Putnam, Sheets
David A. Brow
Credentials: RNA biology and gene expression in eukaryotes
Position title: Professor
Email:
dabrow
Zachary Campbell
Credentials: mRNA control in pain
Position title: Associate Professor - Department of Anesthesiology
Email:
zcampbell
John M. Denu
Credentials: Mechanisms of chromatin dynamics, epigenetic, metabolism and signaling
Position title: Professor (also Epigenetics Theme Leader, Wisconsin Institute for Discovery)
Email:
jmdenu
Catherine A. Fox
Credentials: Conservation and diversity in mechanisms that control the inheritance and expression of eukaryotic chromosomes
Position title: Professor
Email:
cfox
Melissa M. Harrison
Credentials: Transcriptional regulation during development
Position title: Professor
Email:
mharrison3
Gaelen Hess
Credentials: High-throughput functional genomics to investigate DNA repair and pathogenic effectors
Position title: Assistant Professor
Email:
ghess3
Christina M. Hull
Credentials: Virulence and development of human fungal pathogens
Position title: Professor (also Professor of Medical Microbiology & Immunology)
Email:
cmhull
James L. Keck
Credentials: Structural mechanisms of genome maintenance
Position title: Professor
Email:
jlkeck
Tricia Kiley
Credentials: Molecular genetics and biochemistry of oxygen regulated gene expression and transcription activation
Position title: Department Chair & professor
Email:
pjkiley
Peter W. Lewis
Credentials: Mechanisms of chromatin assembly, gene silencing, and epigenetic inheritance
Position title: Professor
Email:
peter.lewis
Andrea A. Putnam
Credentials: Function and regulation of RNA condensates in development
Position title: Assistant Professor (also Center for Quantitative Cell Imaging)
Email:
aaputnam
Michael D. Sheets
Credentials: RNA regulation of cell fate and function
Position title: Professor
Email:
mdsheets