Gaelen Hess

Credentials: High-throughput functional genomics to investigate DNA repair and pathogenic effectors

Position title: Assistant Professor

Email: gaelenh2@stanford.edu

Address:
Wisconsin Institutes for Medical Research (WIMR) west wedge
1111 Highland Avenue

Starting March 2021

Publications

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• Tycko, J., N. DelRosso, G.T. Hess, . Aradhana, A. Banerjee, A. Mukund, M.V. Van, B.K. Ego, D. Yao, K. Spees, P. Suzuki, G.K. Marinov, A. Kundaje, M.C. Bassik, and L. Bintu. (2020). High-Throughput Discovery and Characterization of Human Transcriptional Effectors. Cell, 183: 2020-2035.e16.
• Lahey, L.J., R.E. Mardjuki, X. Wen, G.T. Hess, C. Ritchie, J.A. Carozza, V. Böhnert, M. Maduke, M.C. Bassik, and L. Li. (2020). LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP. Molecular cell, 80: 578-591.e5.
• Debets, M.F., O.Y. Tastan, S.P. Wisnovsky, S.A. Malaker, N. Angelis, L.K.R. Moeckl, J. Choi, H. Flynn, L.J.S. Wagner, G. Bineva-Todd, A. Antonopoulos, A. Cioce, W.M. Browne, Z. Li, D.C. Briggs, H.L. Douglas, G.T. Hess, A.J. Agbay, C. Roustan, S. Kjaer, S.M. Haslam, A.P. Snijders, M.C. Bassik, W.E. Moerner, V.S.W. Li, C.R. Bertozzi, and B. Schumann. (2020). Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation. Proceedings of the National Academy of Sciences of the United States of America, 117: 25293-25301.
• Ferraro, N.M., B.J. Strober, J. Einson, N.S. Abell, F. Aguet, A.N. Barbeira, M. Brandt, M. Bucan, S.E. Castel, J.R. Davis, E. Greenwald, G.T. Hess, A.T. Hilliard, R.L. Kember, B. Kotis, Y. Park, G. Peloso, S. Ramdas, A.J. Scott, C. Smail, E.K. Tsang, S.M. Zekavat, M. Ziosi, . Aradhana, . , K.G. Ardlie, T.L. Assimes, M.C. Bassik, C.D. Brown, A. Correa, I. Hall, H.K. Im, X. Li, P. Natarajan, . , T. Lappalainen, P. Mohammadi, S.B. Montgomery, and A. Battle. (2020). Transcriptomic signatures across human tissues identify functional rare genetic variation. Science (New York, N.Y.), 369: .
• Morgens, D.W., C. Chan, A.J. Kane, N.R. Weir, A. Li, M.M. Dubreuil, C.K. Tsui, G.T. Hess, A. Lavertu, K. Han, N. Polyakov, J. Zhou, E.L. Handy, P. Alabi, A. Dombroski, D. Yao, R.B. Altman, J.K. Sello, V. Denic, and M.C. Bassik. (2019). Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins. eLife, 8: .
• Tycko, J., M. Wainberg, G.K. Marinov, O. Ursu, G.T. Hess, B.K. Ego, . Aradhana, A. Li, A. Truong, A.E. Trevino, K. Spees, D. Yao, I.M. Kaplow, P.G. Greenside, D.W. Morgens, D.H. Phanstiel, M.P. Snyder, L. Bintu, W.J. Greenleaf, A. Kundaje, and M.C. Bassik. (2019). Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements. Nature communications, 10: 4063.
• Ritchie, C., A.F. Cordova, G.T. Hess, M.C. Bassik, and L. Li. (2019). SLC19A1 Is an Importer of the Immunotransmitter cGAMP. Molecular cell, 75: 372-381.e5.
• Breslow, D.K., S. Hoogendoorn, A.R. Kopp, D.W. Morgens, B.K. Vu, M.C. Kennedy, K. Han, A. Li, G.T. Hess, M.C. Bassik, J.K. Chen, and M.V. Nachury. (2018). A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Nature genetics, 50: 460-471.
• Li, X., Y. Kim, E.K. Tsang, J.R. Davis, F.N. Damani, C. Chiang, G.T. Hess, Z. Zappala, B.J. Strober, A.J. Scott, A. Li, A. Ganna, M.C. Bassik, J.D. Merker, . , . , . , . , . , . , . , . , . , . , . , . , . , . , . , . , . , I.M. Hall, A. Battle, and S.B. Montgomery. (2017). The impact of rare variation on gene expression across tissues. Nature, 550: 239-243.
• Hess, G.T., J. Tycko, D. Yao, and M.C. Bassik. (2017). Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes. Molecular cell, 68: 26-43.