Computational and Systems Biology

Living systems are dynamic and complex, and their behavior may be hard to predict from the properties of individual parts. In particular, biochemical interaction networks may give rise to unexpected properties in the presence of complex interconnections and feedbacks between the genes, proteins, and metabolites involved in these networks. Computational and systems biology analyses biochemical systems (such as networks of metabolites, proteins and enzymes which comprise metabolism, signal transduction pathways and gene regulatory networks) by using genomics, proteomics, and metabolomics data together with computational and mathematical tools, in order to understand their emergent properties due to complex connections among different cellular processes.

Relevant Labs: Coon, Craciun, Fox, Harrison, Hess, Kiley, Mosher

Joshua J. Coon

Credentials: Bioanalytical chemistry, mass spectrometry and proteomics

Position title: Professor

Email: jcoon@chem.wisc.edu

Gheorghe Craciun

Credentials: Mathematical and computational methods in biology

Position title: Professor (also Professor of Mathematics)

Email: craciun@math.wisc.edu

Catherine A. Fox

Credentials: Conservation and diversity in mechanisms that control the inheritance and expression of eukaryotic chromosomes

Position title: Professor

Email: cfox@wisc.edu

Melissa M. Harrison

Credentials: Transcriptional regulation during development

Position title: Associate Professor

Email: mharrison3@wisc.edu

Gaelen Hess

Credentials: High-throughput functional genomics to investigate DNA repair and pathogenic effectors

Position title: Assistant Professor

Email: ghess3@wisc.edu

Tricia Kiley

Credentials: Molecular genetics and biochemistry of oxygen regulated gene expression and transcription activation

Position title: Professor and Chair

Email: pjkiley@wisc.edu

Deane F. Mosher

Credentials: Extracellular matrix; cell adhesion

Position title: Professor (also Medicine)

Email: dfm1@medicine.wisc.edu