| 1921 | Harold C. Bradley founded the Department of Physiological Chemistry and became its first Chair. | |
| 1924 | First Ph.D. in the Department of Physiological Chemistry is awarded to Alrick Brynhjolf Hertzman. | |
| 1932 | Marian Esther Stark is the first woman to receive a Ph.D. in the Department of Physiological Chemistry. | |
| 1942 | The author of the definitive series Principles in Biochemistry, Albert L. Lehninger, receives his Ph.D. in Physiological Chemistry from UW-Madison. | |
| 1947 | Philip P. Cohen succeeds Dr. Bradley as Chair. | |
| 1975 | Harry J. Karavolas becomes Chair of the Department. | |
| 1979 | Elizabeth A. Craig becomes the first female faculty member hired in Physiological Chemistry. | |
| 1991 | The department name is changed from Physiological to Biomolecular Chemistry. | |
| 1996 | Elizabeth Craig assumes the position of Chair of the department. | |
| 2002 | Robert H. Fillingame becomes Chair. | |
| 2012 | Biomolecular Chemistry moves into a new $112 million state of the art research complex (Biochemical Sciences) on Henry Mall. | |
| 2013 | Patricia J. Kiley becomes Chair. |