Proteins are linear chains of amino acids that fold into complex three-dimensional structures associated with particular functions. Extensive structural analyses of proteins by X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy have revealed that many proteins are modular, and consist of domains that fold independently.
The Department of Biomolecular Chemistry and the Center for Human Genomics and Precision Medicine are pleased to announce that Galen Hess of Stanford University will be joining our faculty as an assistant professor in January …
Removing a gene from the cells that produce insulin prevents mice from developing Type 1 diabetes by sparing the cells an attack from their own immune system, a new UW–Madison study shows. The cellular sleight …
A report today (June 27) in PLOS Pathogens shows how inhaled fungal spores exit the lung and trigger a fatal infection in mice. The study solves a mystery of mycology: Why are spores of a certain fungal strain deadly while the yeast form of that same fungus is harmless? Study leader Christina Hull, professor of biomolecular chemistry and medical microbiology and immunology at the University of Wisconsin–Madison, focuses on Cryptococcus, the most deadly inhaled fungus. The short answer, she says, is that lung macrophages abandon their posts as bodyguards and begin smuggling spores into the bloodstream.
A molecular basis underlying the neurodegenerative condition hereditary spastic paraplegia (HSP) has been identified in a study by University of Wisconsin School of Medicine and Public Health researchers. The research, published in Cell Reports, shows how a mutation in the TFG gene – one of several linked to HSP – impairs neurons from forming the structures needed to transmit signals properly.
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BMC Chair Patricia Kiley was among six UW-Madison Scholars elected as 2020 Fellows of the American Association for the Advancement of Science (AAAS). According to AAAS, Dr. Kiley is being recognized for her distinguished contributions …November 24, 2020
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