Solving new protein structure with NMR spectroscopy
Proteins are linear chains of amino acids that fold into complex three-dimensional structures associated with particular functions. Extensive structural analyses of proteins by X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy have revealed that many proteins are modular, and consist of domains that fold independently.
News
Galen Hess joins the faculty of Biomolecular Chemistry as new assistant professor
The Department of Biomolecular Chemistry and the Center for Human Genomics and Precision Medicine are pleased to announce that Galen Hess of Stanford University will be joining our faculty as an assistant professor in January …
Deleting a gene prevents Type 1 diabetes in mice by disguising insulin-producing cells
Removing a gene from the cells that produce insulin prevents mice from developing Type 1 diabetes by sparing the cells an attack from their own immune system, a new UW–Madison study shows. The cellular sleight …
A Trojan Horse? Immune cells ferry deadline fungus from mouse lung into the blood
A report today (June 27) in PLOS Pathogens shows how inhaled fungal spores exit the lung and trigger a fatal infection in mice. The study solves a mystery of mycology: Why are spores of a certain fungal strain deadly while the yeast form of that same fungus is harmless? Study leader Christina Hull, professor of biomolecular chemistry and medical microbiology and immunology at the University of Wisconsin–Madison, focuses on Cryptococcus, the most deadly inhaled fungus. The short answer, she says, is that lung macrophages abandon their posts as bodyguards and begin smuggling spores into the bloodstream.
Blockages in nerve-cell protein ‘factory’ ipmlicated in neurodegenerative disease
A molecular basis underlying the neurodegenerative condition hereditary spastic paraplegia (HSP) has been identified in a study by University of Wisconsin School of Medicine and Public Health researchers. The research, published in Cell Reports, shows how a mutation in the TFG gene – one of several linked to HSP – impairs neurons from forming the structures needed to transmit signals properly.
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Awards
BMC Chair Patricia Kiley Named 2020 AAAS Fellow
BMC Chair Patricia Kiley was among six UW-Madison Scholars elected as 2020 Fellows of the American Association for the Advancement of Science (AAAS). According to AAAS, Dr. Kiley is being recognized for her distinguished contributions …
November 24, 2020Coon Recipient of HUPO Award
Professor of Biomolecular Chemistry Josh Coon has been awarded a HUPO by the Human Proteome Organization in recognition of outstanding effort and achievement in the field of proteomics. Press release
September 6, 2018- View more awards