Membrane Biology and Cell Signaling

The ability of cells to sense and react to their surroundings governs their capacity to proliferate, develop, differentiate, and maintain tissue homeostasis. Deficiencies in appropriately translating environmental cues underlie many forms of cancer, neurodegeneration, and immune dysfunction. Our faculty members study the mechanistic basis of signal transduction using a diverse array of models, including E. coli, pathogenic fungi, C. elegans, and mammalian cells. The critical signaling that occurs in response to external stimuli is often initiated at the surface of cells and traverses a network of membrane bound compartments, to ultimately elicit changes in cellular gene expression and metabolism. How these signaling pathways are effectively integrated to facilitate a defined cellular response is a major focus of our membrane biology and cell signaling faculty.

Relevant Labs: Audhya, Engin, Galmozzi, Merrins, Mosher, Putnam

Anjon (Jon) Audhya

Credentials: Regulation of membrane transport during development and disease

Position title: Professor and Senior Associate Dean for Basic Research, Biotechnology, and Graduate Studies, University of Wisconsin School of Medicine and Public Health


Feyza Engin

Credentials: Cellular stress responses, organelle dysfunction and interaction, beta cell function and survival, diabetes

Position title: Associate Professor (also Medicine)


Andrea Galmozzi

Credentials: Intracellular trafficking of signaling metabolites

Position title: Assistant Professor - Department of Medicine


Matthew J. Merrins

Credentials: Metabolic regulation of insulin secretion in aging, obesity, and diabetes

Position title: Associate Professor - Department of Medicine


Deane F. Mosher

Credentials: Extracellular matrix; cell adhesion

Position title: Professor (also Medicine)


Andrea A. Putnam

Credentials: Function and regulation of RNA condensates in development

Position title: Assistant Professor (also Center for Quantitative Cell Imaging)