In a collaboration between the Harrison and Lewis laboratories recently published in GENETICS they describe a Drosophila model of mutations that cause pediatric diffuse midline gliomas by inhibiting the deeply conserved PRC2 enzyme. Using this model and the power of Drosophila genetics, they performed a screen resulting in the identification of conserved genetic modifiers that may inform future therapeutic strategies.
Here is a link to the Inside UW and to the GENETICS paper itself.