Deane F. Mosher
Credentials: Extracellular matrix; cell adhesion
Position title: Professor (also Medicine)
Email: dfm1@medicine.wisc.edu
Phone: (608) 262-1576
Address:
5428A Biochemical Sciences Building
440 Henry Mall, Madison, WI 53706
The Mosher Lab Website
Education
• M.D. 1968, Harvard Medical School
• Postdoctoral 1970-72, Harvard Medical School (Elkan Blout)
Honors & Awards
1978-1983 Established Investigatorship, American Heart Association (AHA) and its Wisconsin Affiliate
1982-1987 H.I. Romnes Fellow, University of Wisconsin
1983 Contributions to Hemostasis Award, International Society of Thrombosis and Hemostasis
1997-present Robert F. Schilling WARF Professor of Medicine, University of Wisconsin
1998 M.D. (Honorary), Lund University, Sweden
2006 Mentoring in the Basic Sciences (1st annual award), American Society of Hematology
2015 Fellow, American Association for the Advancement of Science
2016 Dean’s Legacy Award for Excellence in Medical Student Research Mentorship, School of Medicine and Public Health, University of Wisconsin
Research Interests
My laboratory has been a leader in characterization of structure and function of molecules of blood plasma, platelets, and extracellular matrix. We are best known for studies of fibronectin, thrombospondins, and vitronectin and participate in collaborative studies that utilize the reagents and expertise that we have developed over the years..
For the past two decades, we have worked closely with colleagues in Allergy and Pulmonary and Critical Care Medicine to study activation and trafficking of eosinophils in asthma. Current asthma-related projects include characterizing the proteomes and phosphoproteomes of resting and activated eosinophils (in collaboration with the Josh Coon laboratory); describing the molecular anatomy of and signaling behind the radical changes in eosinophils that occur upon activation with cytokines, chemokines, and other mediators; exploring effects of interactions with periostin, an extracellular matrix protein deposited in the asthmatic lung, on behavior of eosinophils; and identification of biomarkers that differentiate among different types and stages of asthma. In addition, we study adhesion to extracellular matrix proteins of bacteria that are respiratory pathogens or commensal to the bronchial tree.
Publications
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- Johansson, M.W., J. Balnis, L.K. Muehlbauer, Y.V. Bukhman, M.S. Stefely, K.A. Overmyer, R. Vancavage, A. Tiwari, A.R. Adhikari, P.J. Feustel, B.S. Schwartz, J.J. Coon, R. Stewart, A. Jaitovich, and D.F. Mosher. (2023). Decreased plasma cartilage acidic protein 1 in COVID-19. Physiological reports, 11: e15814.
- Resovi, A., P. Persichitti, L. Brunelli, L. Minoli, P. Borsotti, G. Garattini, M. Tironi, E. Dugnani, M. Redegalli, G. De Simone, R. Pastorelli, M.R. Bani, L. Piemonti, D.F. Mosher, R. Giavazzi, G. Taraboletti, and D. Belotti. (2023). Fibronectin fragments generated by pancreatic trypsin act as endogenous inhibitors of pancreatic tumor growth. Journal of experimental & clinical cancer research : CR, 42: 201.
- Zhang, J., Z.R. Gregorich, R. Tao, G.C. Kim, P.A. Lalit, J.L. Carvalho, Y. Markandeya, D.F. Mosher, S.P. Palecek, and T.J. Kamp. (2022). Cardiac differentiation of human pluripotent stem cells using defined extracellular matrix proteins reveals essential role of fibronectin. eLife, 11: .
- Esnault, S., P.S. Fichtinger, K.T. Barretto, F.J. Fogerty, K. Bernau, D.F. Mosher, S.K. Mathur, N. Sandbo, and N.N. Jarjour. (2022). Autophagy Protects against Eosinophil Cytolysis and Release of DNA. Cells, 11: .
- Houseright, R.A., V. Miskolci, O. Mulvaney, V. Bortnov, D.F. Mosher, J. Rindy, D.A. Bennin, and A. Huttenlocher. (2021). Myeloid-derived growth factor regulates neutrophil motility in interstitial tissue damage. The Journal of cell biology, 220: .
- Bartig, K.A., K.E. Lee, D.F. Mosher, S.K. Mathur, and M.W. Johansson. (2021). Platelet association with leukocytes in active eosinophilic esophagitis. PloS one, 16: e0250521.
- Overmyer, K.A., E. Shishkova, I.J. Miller, J. Balnis, M.N. Bernstein, T.M. Peters-Clarke, J.G. Meyer, Q. Quan, L.K. Muehlbauer, E.A. Trujillo, Y. He, A. Chopra, H.C. Chieng, A. Tiwari, M.A. Judson, B. Paulson, D.R. Brademan, Y. Zhu, L.R. Serrano, V. Linke, L.A. Drake, A.P. Adam, B.S. Schwartz, H.A. Singer, S. Swanson, D.F. Mosher, R. Stewart, J.J. Coon, and A. Jaitovich. (2021). Large-Scale Multi-omic Analysis of COVID-19 Severity. Cell systems, 12: 23-40.e7.
- Barretto, K.T., D.F. Mosher, N.N. Jarjour, C.S. Curran, S. Esnault, and M.W. Johansson. (2021). Observation and Quantification of Eosinophil Motility. Methods in molecular biology (Clifton, N.J.), 2241: 139-148.
- Overmyer, K.A., E. Shishkova, I.J. Miller, J. Balnis, M.N. Bernstein, T.M. Peters-Clarke, J.G. Meyer, Q. Quan, L.K. Muehlbauer, E.A. Trujillo, Y. He, A. Chopra, H.C. Chieng, A. Tiwari, M.A. Judson, B. Paulson, D.R. Brademan, Y. Zhu, L.R. Serrano, V. Linke, L.A. Drake, A.P. Adam, B.S. Schwartz, H.A. Singer, S. Swanson, D.F. Mosher, R. Stewart, J.J. Coon, and A. Jaitovich. (2020). Large-scale Multi-omic Analysis of COVID-19 Severity. medRxiv : the preprint server for health sciences, .
- Johansson, M.W., E.M. McKernan, P.S. Fichtinger, E.L. Angulo, J.L. Bagley, K.E. Lee, M.D. Evans, L.D. Lomeli, D.F. Mosher, S.M. Cook, E.A. Gaumnitz, and S.K. Mathur. (2020). α-Integrin (CD41) associated with blood eosinophils is a potential biomarker for disease activity in eosinophilic esophagitis. The Journal of allergy and clinical immunology, 145: 1699-1701.