Deane F. Mosher
Credentials: Extracellular matrix; cell adhesion
Position title: Professor (also Medicine)
Phone: (608) 262-1576
5428A Biochemical Sciences Building
440 Henry Mall, Madison, WI 53706
• M.D. 1968, Harvard Medical School
• Postdoctoral 1970-72, Harvard Medical School (Elkan Blout)
Honors & Awards
• Fellow, American Association for the Advancement of Science, 2015
• Mentoring in the Basic Sciences, American Society of Hematology, 2006
• M.D. (Honorary), Lund University, Sweden, 1998
• R.F. Schilling WARF Professor, 1997
• H.I. Romnes Fellow,1982-87
• Established Investigator, American Heart Association and its Wisconsin Affiliate, 1978-83
My laboratory has been a leader in characterization of structure and function of molecules of blood plasma, platelets, and extracellular matrix. We are best known for studies of fibronectin, thrombospondins, and vitronectin and participate in collaborative studies that utilize the reagents and expertise that we have developed over the years..
For the past two decades, we have worked closely with colleagues in Allergy and Pulmonary and Critical Care Medicine to study activation and trafficking of eosinophils in asthma. Current asthma-related projects include characterizing the proteomes and phosphoproteomes of resting and activated eosinophils (in collaboration with the Josh Coon laboratory); describing the molecular anatomy of and signaling behind the radical changes in eosinophils that occur upon activation with cytokines, chemokines, and other mediators; exploring effects of interactions with periostin, an extracellular matrix protein deposited in the asthmatic lung, on behavior of eosinophils; and identification of biomarkers that differentiate among different types and stages of asthma. In addition, we study adhesion to extracellular matrix proteins of bacteria that are respiratory pathogens or commensal to the bronchial tree.
Perform a customized PubMed literature search for Deane F. Mosher
- Overmyer, K.A., E. Shishkova, I.J. Miller, J. Balnis, M.N. Bernstein, T.M. Peters-Clarke, J.G. Meyer, Q. Quan, L.K. Muehlbauer, E.A. Trujillo, Y. He, A. Chopra, H.C. Chieng, A. Tiwari, M.A. Judson, B. Paulson, D.R. Brademan, Y. Zhu, L.R. Serrano, V. Linke, L.A. Drake, A.P. Adam, B.S. Schwartz, H.A. Singer, S. Swanson, D.F. Mosher, R. Stewart, J.J. Coon, and A. Jaitovich. (2021). Large-Scale Multi-omic Analysis of COVID-19 Severity. Cell systems, 12: 23-40.e7.
- Overmyer, K.A., E. Shishkova, I.J. Miller, J. Balnis, M.N. Bernstein, T.M. Peters-Clarke, J.G. Meyer, Q. Quan, L.K. Muehlbauer, E.A. Trujillo, Y. He, A. Chopra, H.C. Chieng, A. Tiwari, M.A. Judson, B. Paulson, D.R. Brademan, Y. Zhu, L.R. Serrano, V. Linke, L.A. Drake, A.P. Adam, B.S. Schwartz, H.A. Singer, S. Swanson, D.F. Mosher, R. Stewart, J.J. Coon, and A. Jaitovich. (2020). Large-scale Multi-omic Analysis of COVID-19 Severity. medRxiv : the preprint server for health sciences, .
- Johansson, M.W., E.M. McKernan, P.S. Fichtinger, E.L. Angulo, J.L. Bagley, K.E. Lee, M.D. Evans, L.D. Lomeli, D.F. Mosher, S.M. Cook, E.A. Gaumnitz, and S.K. Mathur. (2020). α-Integrin (CD41) associated with blood eosinophils is a potential biomarker for disease activity in eosinophilic esophagitis. The Journal of allergy and clinical immunology, 145: 1699-1701.
- Esnault, S., J.P. Leet, M.W. Johansson, K.T. Barretto, P.S. Fichtinger, F.J. Fogerty, K. Bernau, S.K. Mathur, D.F. Mosher, N. Sandbo, and N.N. Jarjour. (2020). Eosinophil cytolysis on Immunoglobulin G is associated with microtubule formation and suppression of rho-associated protein kinase signalling. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 50: 198-212.
- Johansson, M.W., B.M. Grill, K.T. Barretto, M.C. Favour, H.M. Schira, C.M. Swanson, K.E. Lee, R.L. Sorkness, D.F. Mosher, L.C. Denlinger, and N.N. Jarjour. (2020). Plasma P-Selectin Is Inversely Associated with Lung Function and Corticosteroid Responsiveness in Asthma. International archives of allergy and immunology, 181: 879-887.
- Bortnov, V., M. Tonelli, W. Lee, Z. Lin, D.S. Annis, O.N. Demerdash, A. Bateman, J.C. Mitchell, Y. Ge, J.L. Markley, and D.F. Mosher. (2019). Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum. Nature communications, 10: 5612.
- Wang, L.W., S. Nandadasa, D.S. Annis, J. Dubail, D.F. Mosher, B.B. Willard, and S.S. Apte. (2019). A disintegrin-like and metalloproteinase domain with thrombospondin type 1 motif 9 (ADAMTS9) regulates fibronectin fibrillogenesis and turnover. The Journal of biological chemistry, 294: 9924-9936.
- Rusnati, M., P. Borsotti, E. Moroni, C. Foglieni, P. Chiodelli, L. Carminati, D. Pinessi, D.S. Annis, G. Paiardi, A. Bugatti, A. Gori, R. Longhi, D. Belotti, D.F. Mosher, G. Colombo, and G. Taraboletti. (2019). The calcium-binding type III repeats domain of thrombospondin-2 binds to fibroblast growth factor 2 (FGF2). Angiogenesis, 22: 133-144.
- Fossati, G., D. Pozzi, A. Canzi, F. Mirabella, S. Valentino, R. Morini, E. Ghirardini, F. Filipello, M. Moretti, C. Gotti, D.S. Annis, D.F. Mosher, C. Garlanda, B. Bottazzi, G. Taraboletti, A. Mantovani, M. Matteoli, and E. Menna. (2019). Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin. The EMBO journal, 38: .
- Bortnov, V., D.S. Annis, F.J. Fogerty, K.T. Barretto, K.B. Turton, and D.F. Mosher. (2018). Myeloid-derived growth factor is a resident endoplasmic reticulum protein. The Journal of biological chemistry, 293: 13166-13175.