Deane F. Mosher

Credentials: Extracellular matrix; cell adhesion

Position title: Professor (also Medicine)

Email: dfm1@medicine.wisc.edu

Phone: (608) 262-1576

Address:
5428A Biochemical Sciences Building
440 Henry Mall, Madison, WI 53706

The Mosher Lab Website

Education

M.D. 1968, Harvard Medical School
Postdoctoral 1970-72, Harvard Medical School (Elkan Blout)

Honors & Awards

1978 Established Investigatorship, American Heart Association (AHA) and its Wisconsin Affiliate
1982 H.I. Romnes Fellow, University of Wisconsin
1983 Contributions to Hemostasis Award, International Society of Thrombosis and Hemostasis
1997 Robert F. Schilling WARF Professor of Medicine, University of Wisconsin
1998 M.D. (Honorary), Lund University, Sweden
2006 Mentoring in the Basic Sciences (1st annual award), American Society of Hematology
2015 Fellow, American Association for the Advancement of Science
2016 Dean’s Legacy Award for Excellence in Medical Student Research Mentorship, School of Medicine and Public Health, University of Wisconsin

Research Interests

My laboratory has been a leader in characterization of structure and function of molecules of blood plasma, platelets, and extracellular matrix. We are best known for studies of fibronectin, thrombospondins, and vitronectin and participate in collaborative studies that utilize the reagents and expertise that we have developed over the years..

For the past two decades, we have worked closely with colleagues in Allergy and Pulmonary and Critical Care Medicine to study activation and trafficking of eosinophils in asthma. Current asthma-related projects include characterizing the proteomes and phosphoproteomes of resting and activated eosinophils (in collaboration with the Josh Coon laboratory); describing the molecular anatomy of and signaling behind the radical changes in eosinophils that occur upon activation with cytokines, chemokines, and other mediators; exploring effects of interactions with periostin, an extracellular matrix protein deposited in the asthmatic lung, on behavior of eosinophils; and identification of biomarkers that differentiate among different types and stages of asthma. In addition, we study adhesion to extracellular matrix proteins of bacteria that are respiratory pathogens or commensal to the bronchial tree.

Publications

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