# Gheorghe Craciun

Credentials: Mathematical and computational methods in biology

Position title: Professor (also Professor of Mathematics)

Email: craciun@math.wisc.edu

Phone: (608) 265-3391

##### Education

B.S. 1994, University of Bucharest, Romania

Ph.D. 2002, Ohio State University (Martin Feinberg)

Postdoctoral 2002-05, Ohio State University (Avner Friedman)

##### Honors & Awards

2012 Visiting Professor Fellowship, ETH Zurich, Switzerland

2013 Feinberg Foundation Visiting Faculty Fellowship, Weizmann Institute, Israel

2014 Vilas Research Award, University of Wisconsin-Madison

2017 PresentDiscovery Fellow, Wisconsin Institute for Discovery, University of Wisconsin-Madison

2019 Visiting Professor, Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany

2019 Simons Fellow in Mathematics, Simons Foundation

2019 Van Vleck Professorship Prize, University of Wisconsin-Madison

##### Research Interests

Normal cell function is based in large part on the operation of modules consisting of complex networks of biochemical reactions. I am interested in mathematical and computational methods for understanding dynamical properties of biochemical networks, such as gene regulatory networks, signaling pathways, and metabolic networks. For example, I am working on designing algorithms that allow us to relate the topological structure of a biochemical network and its dynamical properties, such as its capacity to exhibit bistability and oscillations, or its sensitivity to noise and other stochastic properties.

In particular, I am considering mathematical and computational models of: cell division and apoptosis, intracellular transport using motor proteins, electrical signals that allow for intercellular communication, and the action of regulatory molecules that are present at very low levels per cell. I am also working on designing algorithms for de novo sequencing of peptides using mass spectrometry data.

##### Publications

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- Haws, S.A., L.J. Miller, D.R. La Luz, V.I. Kuznetsov, R.C. Trievel, G. Craciun, and J.M. Denu. (2023). Intrinsic catalytic properties of histone H3 lysine-9 methyltransferases preserve monomethylation levels under low S-adenosylmethionine.
*The Journal of biological chemistry*, 299: 104938. - Craciun, G., and A. Deshpande. (2022). Homeostasis and injectivity: a reaction network perspective.
*Journal of mathematical biology*, 85: 67. - Joshi, B., and G. Craciun. (2022). Foundations of static and dynamic absolute concentration robustness.
*Journal of mathematical biology*, 85: 53. - Craciun, G., B. Joshi, C. Pantea, and I. Tan. (2022). Multistationarity in Cyclic Sequestration-Transmutation Networks.
*Bulletin of mathematical biology*, 84: 65. - Craciun, G., A. Deshpande, B. Joshi, and P.Y. Yu. (2022). Autocatalytic recombination systems: A reaction network perspective.
*Mathematical biosciences*, 345: 108784. - Craciun, G., J. Jin, and P.Y. Yu. (2021). Uniqueness of weakly reversible and deficiency zero realizations of dynamical systems.
*Mathematical biosciences*, 342: 108720. - Craciun, G., M. Mincheva, C. Pantea, and P.Y. Yu. (2020). Delay stability of reaction systems.
*Mathematical biosciences*, 326: 108387. - Craciun, G., M.D. Johnston, G. Szederkényi, E. Tonello, J. Tóth, and P.Y. Yu. (2019). Realizations of kinetic differential equations.
*Mathematical biosciences and engineering : MBE*, 17: 862-892. - Craciun, G., S. Muller, C. Pantea, and P.Y. Yu. (2019). A generalization of Birchs theorem and vertex-balanced steady states for generalized mass-action systems.
*Mathematical biosciences and engineering : MBE*, 16: 8243-8267. - Johnston, M.D., D.F. Anderson, G. Craciun, and R. Brijder. (2018). Conditions for extinction events in chemical reaction networks with discrete state spaces.
*Journal of mathematical biology*, 76: 1535-1558.