Joshua J. Coon
Credentials: Bioanalytical chemistry, mass spectrometry and proteomics
Position title: Professor
Email: jcoon@chem.wisc.edu
Phone: (608) 263-1718
Address:
4422 Genetics Biotechnology Center
425 Henry Mall, Madison, WI 53706
The Coon Lab Website
Education
• B.S. 1998, Central Michigan University
• Ph.D. 2002, University of Florida
• Postdoctoral Fellow, 2003-2005, University of Virginia
Honors & Awards
2006 Named one of “Tomorrow’s PI’s” by Genome Technology magazine
2007 American Society of Mass Spectrometry Research Award
2007 Beckman Young Investigator
2007 Eli Lilly and Company Young Investigator
2008 NSF CAREER Award
2009 Ken Standing Award, University of Manitoba
2010 Pittsburgh Conference Achievement Award
2010 Philip R. Certain Dean’s Distinguished Faculty Award, UW Madison
2011 Arthur F. Findeis Young Analytical Scientist Award, ACS
2012 Biemann Medal, ASMS
2014 H.I. Romnes Faculty Fellow, UW-Madison
2016 Inaugural NIGMS Maximizing Investigator’s Research Award Winner, NIH
2017 Thomas and Margaret Pyle Chair, Morgridge Institute for Research
2018 F.C. Donders Chair, Utrecht University, The Netherlands
2018 Discovery in Proteomic Sciences Award, Human Proteome Organization
2020 Kellett Mid-Career Award, UW-Madison
2023 Analytical Division Chemical Instrumentation Award, ACS
Research Interests
The sequencing of the human genome marked the beginning of a collective scientific expedition to understand complex organisms. Genes, of course, merely contain the instructions for which proteins will populate the cell. Untangling the multi-faceted networks that regulate complex organisms and their diseases will require innovative technologies to globally monitor many classes of biomolecules, including nucleic acids, proteins, and metabolites. High-throughput technologies for gene and transcript measurement are well-developed and broadly accessible, and, as such, have had a fantastic and transformative impact on modern biology and medicine. For numerous reasons, methods for global analysis of proteins and metabolites – crucial biological effector molecules – are less evolved and markedly less accessible.
The overarching mission of my program is to (1) facilitate expedient, comprehensive analysis of proteins and metabolites by innovating new mass spectrometric technologies and (2) apply these techniques to advance biomedical research.
Publications
Perform a customized PubMed literature search for Joshua J. Coon
- Westphall, M.S., K.W. Lee, C. Hemme, A.Z. Salome, K. Mertz, T. Grant, and J.J. Coon. (2023). Cryogenic Soft Landing Improves Structural Preservation of Protein Complexes. Analytical chemistry, .
- Westphall, M.S., K.W. Lee, A.Z. Salome, J.J. Coon, and T. Grant. (2023). Mass spectrometers as cryoEM grid preparation instruments. Current opinion in structural biology, 83: 102699.
- Fernandez-Fuente, G., K.A. Overmyer, A.J. Lawton, I. Kasza, S.L. Shapiro, P. Gallego-Muñoz, J.J. Coon, J.M. Denu, C.M. Alexander, and L. Puglielli. (2023). The citrate transporters SLC13A5 and SLC25A1 elicit different metabolic responses and phenotypes in the mouse. Communications biology, 6: 926.
- Johansson, M.W., J. Balnis, L.K. Muehlbauer, Y.V. Bukhman, M.S. Stefely, K.A. Overmyer, R. Vancavage, A. Tiwari, A.R. Adhikari, P.J. Feustel, B.S. Schwartz, J.J. Coon, R. Stewart, A. Jaitovich, and D.F. Mosher. (2023). Decreased plasma cartilage acidic protein 1 in COVID-19. Physiological reports, 11: e15814.
- Mathai, C., F. Jourd'heuil, L.G.C. Pham, K. Gilliard, D. Howard, J. Balnis, A. Jaitovich, S.V. Chittur, M. Rilley, R. Peredo-Wende, I. Ammoura, S.J. Shin, M. Barroso, J. Barra, E. Shishkova, J.J. Coon, R.I. Lopez-Soler, and D. Jourd'heuil. (2023). Regulation of DNA damage and transcriptional output in the vasculature through a cytoglobin-HMGB2 axis. Redox biology, 65: 102838.
- Merrifield, J.L., E.B. Pimentel, T.M. Peters-Clarke, D.J. Nesbitt, J.J. Coon, and J.D. Martell. (2023). DNA-Compatible Copper/TEMPO Oxidation for DNA-Encoded Libraries. Bioconjugate chemistry, 34: 1380-1386.
- Zhu, Y., A. Jen, K.A. Overmyer, A.W. Gao, E. Shishkova, J. Auwerx, and J.J. Coon. (2023). Mass Spectrometry-Based Multi-omics Integration with a Single Set of C. elegans Samples. Analytical chemistry, 95: 10930-10938.
- Westphall, M.S., A.Z. Salome, K.W. Lee, T. Grant, and J.J. Coon. (2023). Towards Cryogenic Soft Landing of Native Protein Complexes. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 29: 1013.
- Westphall, M.S., K.W. Lee, C. Hemme, A.Z. Salome, K. Mertz, T. Grant, and J.J. Coon. (2023). Cryogenic Soft Landing Improves Structural Preservation of Protein Complexes. bioRxiv : the preprint server for biology, .
- He, Y., E. Shishkova, T.M. Peters-Clarke, D.R. Brademan, M.S. Westphall, D. Bergen, J. Huang, R. Huguet, M.W. Senko, V. Zabrouskov, G.C. McAlister, and J.J. Coon. (2023). Evaluation of the Orbitrap Ascend Tribrid Mass Spectrometer for Shotgun Proteomics. Analytical chemistry, 95: 10655-10663.