Joshua J. Coon
Credentials: Bioanalytical chemistry, mass spectrometry and proteomics
Position title: Professor
Email: jcoon@chem.wisc.edu
Phone: (608) 263-1718
Address:
4422 Genetics Biotechnology Center
425 Henry Mall, Madison, WI 53706
The Coon Lab Website
Education
• B.S. 1998, Central Michigan University
• Ph.D. 2002, University of Florida
• Postdoctoral Fellow, 2003-2005, University of Virginia
Honors & Awards
• Ruth L. Kirchstein Individual National Research Service Award, 2003
• Named as one of Tomorrow’s PIs by Genome Technology magazine, 2006
• American Society of Mass Spectrometry Research Award, 2007
• Beckman Young Investigator Award, 2007
• Eli Lilly and Company Young Investigator, 2007
• National Science Foundation Career Award, 2008
• Ken Standing Award, University of Manitoba, 2009
• Philip R. Certain Dean’s Distinguished Faculty Award, 2010
• Pittsburg Conference Achievement Award, 2010
• Arthur F. Findeis Award for Achievements by a Young Analytical Scientist, American Chemical Society, 2011
• Biemann Medal (ASMS), 2012
• WARF Romnes Faculty Fellowship, University of Wisconsin-Madison, 2014
• Thomas and Margaret Pyle Chair at the Morgridge Institute for Research, 2018
Research Interests
The sequencing of the human genome marked the beginning of a collective scientific expedition to understand complex organisms. Genes, of course, merely contain the instructions for which proteins will populate the cell. Untangling the multi-faceted networks that regulate complex organisms and their diseases will require innovative technologies to globally monitor many classes of biomolecules, including nucleic acids, proteins, and metabolites. High-throughput technologies for gene and transcript measurement are well-developed and broadly accessible, and, as such, have had a fantastic and transformative impact on modern biology and medicine. For numerous reasons, methods for global analysis of proteins and metabolites – crucial biological effector molecules – are less evolved and markedly less accessible.
The overarching mission of my program is to (1) facilitate expedient, comprehensive analysis of proteins and metabolites by innovating new mass spectrometric technologies and (2) apply these techniques to advance biomedical research.
Publications
Perform a customized PubMed literature search for Joshua J. Coon
- Lee, K.W., A.Z. Salome, M.S. Westphall, T. Grant, and J.J. Coon. (2023). Onto Grid Purification and 3D Reconstruction of Protein Complexes Using Matrix-Landing Native Mass Spectrometry. Journal of proteome research, 22: 851-856.
- Niemi, N.M., L.R. Serrano, L.K. Muehlbauer, C. Balnis, K.L. Kozul, E.H. Rashan, E. Shishkova, K.L. Schueler, M.P. Keller, A.D. Attie, J. Pagan, J.J. Coon, and D.J. Pagliarini. (2023). Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy. bioRxiv : the preprint server for biology, .
- Zhang, Q., V. Linke, K.A. Overmyer, L.L. Traeger, K. Kasahara, I.J. Miller, D.E. Manson, T.J. Polaske, R.L. Kerby, J.H. Kemis, E.A. Trujillo, T.R. Reddy, J.D. Russell, K.L. Schueler, D.S. Stapleton, M.E. Rabaglia, M. Seldin, D.M. Gatti, G.R. Keele, D.T. Pham, J.P. Gerdt, E.I. Vivas, A.J. Lusis, M.P. Keller, G.A. Churchill, H.E. Blackwell, K.W. Broman, A.D. Attie, J.J. Coon, and F.E. Rey. (2023). Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut. Nature microbiology, 8: 424-440.
- Muehlbauer, L.K., A. Jen, Y. Zhu, Y. He, E. Shishkova, K.A. Overmyer, and J.J. Coon. (2023). Rapid Multi-Omics Sample Preparation for Mass Spectrometry. Analytical chemistry, 95: 659-667.
- Perrin-Stowe, T.I.N., M. Horner, J.J. Coon, L.R. Lynch, A. de Flamingh, N.B. Alexander, E. Golebie, T.M. Swartz, A.C. Bader, and S.J. Halsey. (2023). "Where do I even start?" Recommendations for faculty diversifying syllabi in ecology, evolution, and the life sciences. Ecology and evolution, 13: e9719.
- Salome, A.Z., K.W. Lee, T. Grant, M.S. Westphall, and J.J. Coon. (2022). Matrix-Landing Mass Spectrometry for Electron Microscopy Imaging of Native Protein Complexes. Analytical chemistry, 94: 17616-17624.
- Manicki, M., H. Aydin, L.A. Abriata, K.A. Overmyer, R.M. Guerra, J.J. Coon, M. Dal Peraro, A. Frost, and D.J. Pagliarini. (2022). Structure and functionality of a multimeric human COQ7:COQ9 complex. Molecular cell, 82: 4307-4323.e10.
- Chipkar, S., K. Smith, E.M. Whelan, D.J. Debrauske, A. Jen, K.A. Overmyer, A. Senyk, L. Hooker-Moericke, M. Gallmeyer, J.J. Coon, A.D. Jones, T.K. Sato, and R.G. Ong. (2022). Water-soluble saponins accumulate in drought-stressed switchgrass and may inhibit yeast growth during bioethanol production. Biotechnology for biofuels and bioproducts, 15: 116.
- Park, H., F.V. Hundley, Q. Yu, K.A. Overmyer, D.R. Brademan, L. Serrano, J.A. Paulo, J.C. Paoli, S. Swarup, J.J. Coon, S.P. Gygi, and J. Wade Harper. (2022). Spatial snapshots of amyloid precursor protein intramembrane processing via early endosome proteomics. Nature communications, 13: 6112.
- Muehlbauer, L.K., T. Wei, E. Shishkova, J.J. Coon, and P.F. Lambert. (2022). IQGAP1 and RNA Splicing in the Context of Head and Neck via Phosphoproteomics. Journal of proteome research, 21: 2211-2223.