Joshua J. Coon
Credentials: Bioanalytical chemistry, mass spectrometry and proteomics
Position title: Professor
Phone: (608) 263-1718
4422 Genetics Biotechnology Center
425 Henry Mall, Madison, WI 53706
• B.S. 1998, Central Michigan University
• Ph.D. 2002, University of Florida
• Postdoctoral Fellow, 2003-2005, University of Virginia
Honors & Awards
• Ruth L. Kirchstein Individual National Research Service Award, 2003
• Named as one of Tomorrow’s PIs by Genome Technology magazine, 2006
• American Society of Mass Spectrometry Research Award, 2007
• Beckman Young Investigator Award, 2007
• Eli Lilly and Company Young Investigator, 2007
• National Science Foundation Career Award, 2008
• Ken Standing Award, University of Manitoba, 2009
• Philip R. Certain Dean’s Distinguished Faculty Award, 2010
• Pittsburg Conference Achievement Award, 2010
• Arthur F. Findeis Award for Achievements by a Young Analytical Scientist, American Chemical Society, 2011
• Biemann Medal (ASMS), 2012
• WARF Romnes Faculty Fellowship, University of Wisconsin-Madison, 2014
• Thomas and Margaret Pyle Chair at the Morgridge Institute for Research, 2018
The sequencing of the human genome marked the beginning of a collective scientific expedition to understand complex organisms. Genes, of course, merely contain the instructions for which proteins will populate the cell. Untangling the multi-faceted networks that regulate complex organisms and their diseases will require innovative technologies to globally monitor many classes of biomolecules, including nucleic acids, proteins, and metabolites. High-throughput technologies for gene and transcript measurement are well-developed and broadly accessible, and, as such, have had a fantastic and transformative impact on modern biology and medicine. For numerous reasons, methods for global analysis of proteins and metabolites – crucial biological effector molecules – are less evolved and markedly less accessible.
The overarching mission of my program is to (1) facilitate expedient, comprehensive analysis of proteins and metabolites by innovating new mass spectrometric technologies and (2) apply these techniques to advance biomedical research.
Perform a customized PubMed literature search for Joshua J. Coon
- Frazier, K., A. Kambal, E.A. Zale, J.F. Pierre, N. Hubert, S. Miyoshi, J. Miyoshi, D.L. Ringus, D. Harris, K. Yang, K. Carroll, J.B. Hermanson, J.S. Chlystek, K.A. Overmyer, C.M. Cham, M.W. Musch, J.J. Coon, E.B. Chang, and V.A. Leone. (2022). High-fat diet disrupts REG3γ and gut microbial rhythms promoting metabolic dysfunction. Cell host & microbe, 30: 809-823.e6.
- Rensvold, J.W., E. Shishkova, Y. Sverchkov, I.J. Miller, A. Cetinkaya, A. Pyle, M. Manicki, D.R. Brademan, Y. Alanay, J. Raiman, A. Jochem, P.D. Hutchins, S.R. Peters, V. Linke, K.A. Overmyer, A.Z. Salome, A.S. Hebert, C.E. Vincent, N.W. Kwiecien, M.J.P. Rush, M.S. Westphall, M. Craven, N.A. Akarsu, R.W. Taylor, J.J. Coon, and D.J. Pagliarini. (2022). Defining mitochondrial protein functions through deep multiomic profiling. Nature, 606: 382-388.
- Solomon, P.E., L.L. Kirkemo, G.M. Wilson, K.K. Leung, M.H. Almond, L.C. Sayles, E.A. Sweet-Cordero, O.S. Rosenberg, J.J. Coon, and J.A. Wells. (2022). Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation. Molecular & cellular proteomics : MCP, 21: 100247.
- Bradberry, M.M., S. Mishra, Z. Zhang, L. Wu, J.M. McKetney, M.M. Vestling, J.J. Coon, and E.R. Chapman. (2022). Rapid and Gentle Immunopurification of Brain Synaptic Vesicles. The Journal of neuroscience : the official journal of the Society for Neuroscience, 42: 3512-3522.
- Westphall, M.S., K.W. Lee, A.Z. Salome, J.M. Lodge, T. Grant, and J.J. Coon. (2022). Three-dimensional structure determination of protein complexes using matrix-landing mass spectrometry. Nature communications, 13: 2276.
- Wen, Z., R. Finn, X. Gao, L. Li, A. Hebert, E.A. Ranheim, Y. Zhou, G. Yun, J.P. Roose, J.J. Coon, R. Shiang, R. Wen, M. Yu, D. Wang, and J. Zhang. (2022). Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in Nras mice. Leukemia, 36: 1167-1170.
- Gambacorta, F.V., E.R. Wagner, T.B. Jacobson, M. Tremaine, L.K. Muehlbauer, M.A. McGee, J.J. Baerwald, R.L. Wrobel, J.F. Wolters, M. Place, J.J. Dietrich, D. Xie, J. Serate, S. Gajbhiye, L. Liu, M. Vang-Smith, J.J. Coon, Y. Zhang, A.P. Gasch, D. Amador-Noguez, C.T. Hittinger, T.K. Sato, and B.F. Pfleger. (2022). Comparative functional genomics identifies an iron-limited bottleneck in a Saccharomyces cerevisiae strain with a cytosolic-localized isobutanol pathway. Synthetic and systems biotechnology, 7: 738-749.
- Schimke, L.F., A.H.C. Marques, G.C. Baiocchi, C.A. de Souza Prado, D.L.M. Fonseca, P.P. Freire, D. Rodrigues Plaça, I. Salerno Filgueiras, R. Coelho Salgado, G. Jansen-Marques, A.E. Rocha Oliveira, J.P.S. Peron, G. Cabral-Miranda, J.A.M. Barbuto, N.O.S. Camara, V.L.G. Calich, H.D. Ochs, A. Condino-Neto, K.A. Overmyer, J.J. Coon, J. Balnis, A. Jaitovich, J. Schulte-Schrepping, T. Ulas, J.L. Schultze, H.I. Nakaya, I. Jurisica, and O. Cabral-Marques. (2022). Severe COVID-19 Shares a Common Neutrophil Activation Signature with Other Acute Inflammatory States. Cells, 11: .
- Zhang, Z., K.M. Dubiak, E. Shishkova, P.W. Huber, J.J. Coon, and N.J. Dovichi. (2022). High-Throughput, Comprehensive Single-Cell Proteomic Analysis of Xenopus laevis Embryos at the 50-Cell Stage Using a Microplate-Based MICROFASP System. Analytical chemistry, 94: 3254-3259.
- Lee, K.W., T.M. Peters-Clarke, K.L. Mertz, G.C. McAlister, J.E.P. Syka, M.S. Westphall, and J.J. Coon. (2022). Infrared Photoactivation Boosts Reporter Ion Yield in Isobaric Tagging. Analytical chemistry, 94: 3328-3334.