Joshua J. Coon
Credentials: Bioanalytical chemistry, mass spectrometry and proteomics
Position title: Professor
Phone: (608) 263-1718
4422 Genetics Biotechnology Center
425 Henry Mall, Madison, WI 53706
• B.S. 1998, Central Michigan University
• Ph.D. 2002, University of Florida
• Postdoctoral Fellow, 2003-2005, University of Virginia
Honors & Awards
• Ruth L. Kirchstein Individual National Research Service Award, 2003
• Named as one of Tomorrow’s PIs by Genome Technology magazine, 2006
• American Society of Mass Spectrometry Research Award, 2007
• Beckman Young Investigator Award, 2007
• Eli Lilly and Company Young Investigator, 2007
• National Science Foundation Career Award, 2008
• Ken Standing Award, University of Manitoba, 2009
• Philip R. Certain Dean’s Distinguished Faculty Award, 2010
• Pittsburg Conference Achievement Award, 2010
• Arthur F. Findeis Award for Achievements by a Young Analytical Scientist, American Chemical Society, 2011
• Biemann Medal (ASMS), 2012
• WARF Romnes Faculty Fellowship, University of Wisconsin-Madison, 2014
• Thomas and Margaret Pyle Chair at the Morgridge Institute for Research, 2018
The sequencing of the human genome marked the beginning of a collective scientific expedition to understand complex organisms. Genes, of course, merely contain the instructions for which proteins will populate the cell. Untangling the multi-faceted networks that regulate complex organisms and their diseases will require innovative technologies to globally monitor many classes of biomolecules, including nucleic acids, proteins, and metabolites. High-throughput technologies for gene and transcript measurement are well-developed and broadly accessible, and, as such, have had a fantastic and transformative impact on modern biology and medicine. For numerous reasons, methods for global analysis of proteins and metabolites – crucial biological effector molecules – are less evolved and markedly less accessible.
The overarching mission of my program is to (1) facilitate expedient, comprehensive analysis of proteins and metabolites by innovating new mass spectrometric technologies and (2) apply these techniques to advance biomedical research.
Perform a customized PubMed literature search for Joshua J. Coon
- Wen, Z., G. Yun, A. Hebert, G. Kong, E.A. Ranheim, R. Finn, A. Rajagoplan, S. Li, Y. Zhou, M. Yu, A. Damnernsawad, J.P. Roose, J.J. Coon, R. Wen, D. Wang, and J. Zhang. (2021). Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors. Blood, 137: 3259-3271.
- Lin, K.H., G.M. Wilson, R. Blanco, N.D. Steinert, W.G. Zhu, J.J. Coon, and T.A. Hornberger. (2021). A deep analysis of the proteomic and phosphoproteomic alterations that occur in skeletal muscle after the onset of immobilization. The Journal of physiology, 599: 2887-2906.
- Wong, H.H., S.H. Seet, M. Maier, A. Gurel, R.M. Traspas, C. Lee, S. Zhang, B. Talim, A.Y.T. Loh, C.Y. Chia, T.S. Teoh, D. Sng, J. Rensvold, S. Unal, E. Shishkova, E. Cepni, F.M. Nathan, F.L. Sirota, C. Liang, N. Yarali, P.O. Simsek-Kiper, T. Mitani, S. Ceylaner, O. Arman-Bilir, H. Mbarek, F. Gumruk, S. Efthymiou, D. Uğurlu Çi Men, D. Georgiadou, K. Sotiropoulou, H. Houlden, F. Paul, D. Pehlivan, C. Lainé, G. Chai, N.A. Ali, S.C. Choo, S.S. Keng, B. Boisson, E. Yılmaz, S. Xue, J.J. Coon, T.T.N. Ly, N. Gilani, D. Hasbini, H. Kayserili, M. Zaki, R.J. Isfort, N. Ordonez, K. Tripolszki, P. Bauer, N. Rezaei, S. Seyedpour, G.T. Khotaei, C.C. Bascom, R. Maroofian, M. Chaabouni, A. Alsubhi, W. Eyaid, S. Işıkay, J.G. Gleeson, J.R. Lupski, J.L. Casanova, D.J. Pagliarini, N.A. Akarsu, S. Maurer-Stroh, A. Cetinkaya, A. Bertoli-Avella, A.S. Mathuru, L. Ho, F.A. Bard, and B. Reversade. (2021). Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen storage-associated mitochondriopathy. American journal of human genetics, .
- Mori, H., C.E. Dugan, A. Nishii, A. Benchamana, Z. Li, T.S. Cadenhead, A.K. Das, C.R. Evans, K.A. Overmyer, S.M. Romanelli, S.K. Peterson, D.P. Bagchi, C.A. Corsa, J. Hardij, B.S. Learman, M. El Azzouny, J.J. Coon, K. Inoki, and O.A. MacDougald. (2021). The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures. PLoS biology, 19: e3000988.
- McKetney, J., D.J. Panyard, S.C. Johnson, C.M. Carlsson, C.D. Engelman, and J.J. Coon. (2021). Pilot proteomic analysis of cerebrospinal fluid in Alzheimer's disease. Proteomics. Clinical applications, 15: e2000072.
- Robinson, K.P., A. Jochem, S.E. Johnson, T.R. Reddy, J.D. Russell, J.J. Coon, and D.J. Pagliarini. (2021). Defining intermediates and redundancies in coenzyme Q precursor biosynthesis. The Journal of biological chemistry, 100643.
- He, Y., E.H. Rashan, V. Linke, E. Shishkova, A.S. Hebert, A. Jochem, M.S. Westphall, D.J. Pagliarini, K.A. Overmyer, and J.J. Coon. (2021). Multi-Omic Single-Shot Technology for Integrated Proteome and Lipidome Analysis. Analytical chemistry, 93: 4217-4222.
- Steinert, N.D., G.K. Potts, G.M. Wilson, A.M. Klamen, K.H. Lin, J.B. Hermanson, R.M. McNally, J.J. Coon, and T.A. Hornberger. (2021). Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function. Cell reports, 34: 108796.
- Balnis, J., A.P. Adam, A. Chopra, H.C. Chieng, L.A. Drake, N. Martino, R. Bossardi Ramos, P.J. Feustel, K.A. Overmyer, E. Shishkova, J.J. Coon, H.A. Singer, M.A. Judson, and A. Jaitovich. (2021). Unique inflammatory profile is associated with higher SARS-CoV-2 acute respiratory distress syndrome (ARDS) mortality. American journal of physiology. Regulatory, integrative and comparative physiology, 320: R250-R257.
- Overmyer, K.A., E. Shishkova, I.J. Miller, J. Balnis, M.N. Bernstein, T.M. Peters-Clarke, J.G. Meyer, Q. Quan, L.K. Muehlbauer, E.A. Trujillo, Y. He, A. Chopra, H.C. Chieng, A. Tiwari, M.A. Judson, B. Paulson, D.R. Brademan, Y. Zhu, L.R. Serrano, V. Linke, L.A. Drake, A.P. Adam, B.S. Schwartz, H.A. Singer, S. Swanson, D.F. Mosher, R. Stewart, J.J. Coon, and A. Jaitovich. (2021). Large-Scale Multi-omic Analysis of COVID-19 Severity. Cell systems, 12: 23-40.e7.