Anjon (Jon) Audhya
Credentials: Regulation of membrane transport during development and disease
Position title: Professor and Senior Associate Dean for Basic Research, Biotechnology, and Graduate Studies, University of Wisconsin School of Medicine and Public Health
Email: audhya@wisc.edu
Phone: (608) 262-3761; Dean's Office: (608) 263-9171
Address:
1111 Highland Avenue, 9455 WIMR 53705
The Audhya Lab Website
Education
• B.S. 1997, Brown University, Providence, RI
• Ph.D. 2002, University of California, San Diego (S. Emr)
• Postdoctoral 2003-07, Ludwig Institute for Cancer Research (K. Oegema)
Honors & Awards
• Sigma Xi Honorary Society, 1997
• Bachelor of Science, Magna cum Laude, Brown University, 1997
• Harvey Almy Baker Graduate Fellowship, Brown University, 1997
• National Cancer Institute Training Grant Award, 1998-2002
• Helen Hay Whitney Foundation Post-Doctoral Fellowship, 2004-2007
• DeLill Nasser Award for Professional Development in Genetics, 2006
• March of Dimes Basil O’Connor Starter Scholar Research Award, 2010
• American Heart Association Scientist Development Grant Award, 2010
• Shaw Scientist Award, 2010
• American Cancer Society Research Scholar Award, 2012
• Vilas Associate Award, University of Wisconsin-Madison, 2015
• Vilas Faculty Early Career Investigator Award, University of Wisconsin-Madison, 2016
• H.I. Romnes Faculty Fellowship, UW Graduate School/WARF, 2017
• Tom Wahlig Foundation Advanced Scholarship, 2018
Research Interests
Our laboratory is committed to understanding fundamental mechanisms by which membrane proteins, lipids, and other macromolecules are transported throughout eukaryotic cells. To do so, we take advantage of numerous interdisciplinary approaches, including biochemistry, structural biology, biophysics, genetics, molecular biology and high resolution fluorescence and electron microscopy.
Additionally, we use a variety of experimental systems, ranging from simple animal models (e.g. Caenorhabditis elegans) to human induced pluripotent stem cells (iPSCs). We also aim to recapitulate individual steps of membrane transport in vitro, using recombinant proteins and chemically defined lipids. Our ultimate goal is to identify the regulatory pathways that control membrane deformation, which enable vesicle formation in the endosomal and secretory systems. Although basic research is the cornerstone of our program, we also seek to define pathomechanisms that underlie human disease, focusing on the impact of mutations in key trafficking components that lead to cancer, neurodegeneration, asthma, and diabetes. For more information, please visit our lab webpage: www.audhyalab.org .
Publications
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- Paul, S., A. Audhya, and Q. Cui. (2023). Molecular mechanism of GTP binding- and dimerization-induced enhancement of Sar1-mediated membrane remodeling. Proceedings of the National Academy of Sciences of the United States of America, 120: e2212513120.
- Salamon, R.J., P. Halbe, W. Kasberg, J. Bae, A. Audhya, and A.I. Mahmoud. (2023). Defining Cardiac Nerve Architecture During Development, Disease, and Regeneration. bioRxiv : the preprint server for biology, .
- Lynch, A.M., Y. Zhu, B.G. Lucas, J.D. Winkelman, K. Bai, S.C.T. Martin, S. Block, M.M. Slabodnick, A. Audhya, B. Goldstein, J. Pettitt, M.L. Gardel, and J. Hardin. (2022). TES-1/Tes and ZYX-1/Zyxin protect junctional actin networks under tension during epidermal morphogenesis in the C. elegans embryo. Current biology : CB, 32: 5189-5199.e6.
- Clarke, A.L., M.M. Lettman, and A. Audhya. (2022). Lgd regulates ESCRT-III complex accumulation at multivesicular endosomes to control intralumenal vesicle formation. Molecular biology of the cell, 33: ar144.
- Britigan, E.M.C., J. Wan, D.K. Sam, S.E. Copeland, A.L. Lasek, L.C.F. Hrycyniak, L. Wang, A. Audhya, M.E. Burkard, A. Roopra, and B.A. Weaver. (2022). Increased Aurora B expression reduces substrate phosphorylation and induces chromosomal instability. Frontiers in cell and developmental biology, 10: 1018161.
- Peotter, J.L., I. Pustova, M.M. Lettman, S. Shatadal, M.M. Bradberry, A.D. Winter-Reed, M. Charan, E.E. Sharkey, J.R. Alvin, A.M. Bren, A.K. Oie, E.R. Chapman, M.S. Salamat, and A. Audhya. (2022). TFG regulates secretory and endosomal sorting pathways in neurons to promote their activity and maintenance. Proceedings of the National Academy of Sciences of the United States of America, 119: e2210649119.
- Zhang, R.R., C. Choi, C.L. Brunnquell, R. Hernandez, A.N. Pinchuk, J.G. Grudzinski, P.A. Clark, A.B. McMillan, A. Audhya, J. Jeffrey, J.S. Kuo, and J.P. Weichert. (2022). Next-Generation Cancer Magnetic Resonance Imaging With Tumor-Targeted Alkylphosphocholine Metal Analogs. Investigative radiology, 57: 655-663.
- Shankar, R., M.M. Lettman, W. Whisler, E.B. Frankel, and A. Audhya. (2022). The ESCRT machinery directs quality control over inner nuclear membrane architecture. Cell reports, 38: 110263.
- Mandal, T., S.E. Spagnolie, A. Audhya, and Q. Cui. (2021). Protein-induced membrane curvature in coarse-grained simulations. Biophysical journal, 120: 3211-3221.
- Zhao, M., F. Zhang, R. Zarnowski, K. Barns, R. Jones, J. Fossen, H. Sanchez, S.R. Rajski, A. Audhya, T.S. Bugni, and D.R. Andes. (2021). Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle-mediated trafficking. The Journal of clinical investigation, 131: .