Anjon (Jon) Audhya
Credentials: Regulation of membrane transport during development and disease
Position title: Professor and Senior Associate Dean for Basic Research, Biotechnology, and Graduate Studies, University of Wisconsin School of Medicine and Public Health
Email: audhya@wisc.edu
Phone: (608) 262-3761; Dean's Office: (608) 263-9171
Address:
1111 Highland Avenue, 9455 WIMR 53705
The Audhya Lab Website
Education
• B.S. 1997, Brown University, Providence, RI
• Ph.D. 2002, University of California, San Diego (S. Emr)
• Postdoctoral 2003-07, Ludwig Institute for Cancer Research (K. Oegema)
Honors & Awards
2010 March of Dimes Basil O’Connor Starter Scholar Research Award
2010 American Heart Association Scientist Development Grant Award
2010 Shaw Scientist Award, Greater Milwaukee Foundation
2012 American Cancer Society Research Scholar Award
2015 Vilas Associate Award, University of Wisconsin-Madison
2016 Vilas Faculty Early Career Investigator Award
2016 T32 Training Grant (GM008688) to Support Predoctoral Training in Molecular and Cellular Pharmacology (Renewal)
2017 H. I. Romnes Faculty Fellowship
2018 Tom Wahlig Foundation Advanced Scholarship
2018 S10 Instrumentation Grant (OD025040; An Upright Multiphoton Microscopy System to Support the Biomedical Sciences)
2020 RIDE Scholar, UW-Madison Carbone Cancer Center
2021 T32 Training Grant (GM141013) to support Graduate Training in Molecular and Cellular Pharmacology
2022 Vilas Faculty Mid-Career Investigator Award
2022 Rennebohm Research Professorship
Research Interests
Our laboratory is committed to understanding fundamental mechanisms by which membrane proteins, lipids, and other macromolecules are transported throughout eukaryotic cells. To do so, we take advantage of numerous interdisciplinary approaches, including biochemistry, structural biology, biophysics, genetics, molecular biology and high resolution fluorescence and electron microscopy.
Additionally, we use a variety of experimental systems, ranging from simple animal models (e.g. Caenorhabditis elegans) to human induced pluripotent stem cells (iPSCs). We also aim to recapitulate individual steps of membrane transport in vitro, using recombinant proteins and chemically defined lipids. Our ultimate goal is to identify the regulatory pathways that control membrane deformation, which enable vesicle formation in the endosomal and secretory systems. Although basic research is the cornerstone of our program, we also seek to define pathomechanisms that underlie human disease, focusing on the impact of mutations in key trafficking components that lead to cancer, neurodegeneration, asthma, and diabetes. For more information, please visit our lab webpage: www.audhyalab.org .
Publications
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- Salamon, R.J., P. Halbe, W. Kasberg, J. Bae, A. Audhya, and A.I. Mahmoud. (2023). Parasympathetic and sympathetic axons are bundled in the cardiac ventricles and undergo physiological reinnervation during heart regeneration. iScience, 26: 107709.
- Kasberg, W., P. Luong, M.G. Hanna, K. Minushkin, A. Tsao, R. Shankar, S. Block, and A. Audhya. (2023). The Sar1 GTPase is dispensable for COPII-dependent cargo export from the ER. Cell reports, 42: 112635.
- Kasberg, W., P. Luong, K. Swift, and A. Audhya. (2023). Nutrient deprivation alters the rate of COPII coat assembly to tune secretory protein transport. Research square, .
- Paul, S., A. Audhya, and Q. Cui. (2023). Molecular mechanism of GTP binding- and dimerization-induced enhancement of Sar1-mediated membrane remodeling. Proceedings of the National Academy of Sciences of the United States of America, 120: e2212513120.
- Salamon, R.J., P. Halbe, W. Kasberg, J. Bae, A. Audhya, and A.I. Mahmoud. (2023). Defining Cardiac Nerve Architecture During Development, Disease, and Regeneration. bioRxiv : the preprint server for biology, .
- Lynch, A.M., Y. Zhu, B.G. Lucas, J.D. Winkelman, K. Bai, S.C.T. Martin, S. Block, M.M. Slabodnick, A. Audhya, B. Goldstein, J. Pettitt, M.L. Gardel, and J. Hardin. (2022). TES-1/Tes and ZYX-1/Zyxin protect junctional actin networks under tension during epidermal morphogenesis in the C. elegans embryo. Current biology : CB, 32: 5189-5199.e6.
- Clarke, A.L., M.M. Lettman, and A. Audhya. (2022). Lgd regulates ESCRT-III complex accumulation at multivesicular endosomes to control intralumenal vesicle formation. Molecular biology of the cell, 33: ar144.
- Britigan, E.M.C., J. Wan, D.K. Sam, S.E. Copeland, A.L. Lasek, L.C.F. Hrycyniak, L. Wang, A. Audhya, M.E. Burkard, A. Roopra, and B.A. Weaver. (2022). Increased Aurora B expression reduces substrate phosphorylation and induces chromosomal instability. Frontiers in cell and developmental biology, 10: 1018161.
- Peotter, J.L., I. Pustova, M.M. Lettman, S. Shatadal, M.M. Bradberry, A.D. Winter-Reed, M. Charan, E.E. Sharkey, J.R. Alvin, A.M. Bren, A.K. Oie, E.R. Chapman, M.S. Salamat, and A. Audhya. (2022). TFG regulates secretory and endosomal sorting pathways in neurons to promote their activity and maintenance. Proceedings of the National Academy of Sciences of the United States of America, 119: e2210649119.
- Zhang, R.R., C. Choi, C.L. Brunnquell, R. Hernandez, A.N. Pinchuk, J.G. Grudzinski, P.A. Clark, A.B. McMillan, A. Audhya, J. Jeffrey, J.S. Kuo, and J.P. Weichert. (2022). Next-Generation Cancer Magnetic Resonance Imaging With Tumor-Targeted Alkylphosphocholine Metal Analogs. Investigative radiology, 57: 655-663.