Qualified and interested applicants are invited to send their CV, cover letter, and contact information for three references to Dr. Feyza Engin at firstname.lastname@example.org.
About the Lab
The Engin Laboratory is a dynamic group focused on understanding the role of the unfolded protein response (UPR) signaling pathway in beta cell dysfunction and diabetes. The work involves working with the tissue specific mouse models of the UPR pathway, ER-mitochondria crosstalk and mechanistic studies using cell culture, imaging, biochemical and immunological assays. More information about our research, see our publications (Engin et al., Sci Transl Med, 2013, Lee et al., Cell Metab 2020) and visit our website enginlab.org.
The candidate will investigate the molecular mechanisms of beta cell failure in diabetes in the Engin Lab. The candidate is expected to design and implement strategies to investigate the unfolded protein response in beta cells of recently generated transgenic mouse models of diabetes. He/she is also expected to explore new research areas and seek independent funding as part of their own career development. He/she will 1) assist in the execution of ongoing projects by performing experiments and analyzing data 2) develop novel ideas in line with the projects in the lab, 3) provide training/mentoring to graduate and undergraduate students 4) attend national and international meetings to present data, 5) help Dr. Engin with writing and preparing grants and manuscripts.
The ideal candidate is expected to be a creative, productive and self-motivated individual with the ability to think critically, learn quickly and function both independently and within a team.
Ph.D. or MD/PHD. required in the biochemical sciences with an emphasis on either biochemistry, cell biology, immunology or genetics.
Recent Ph.Ds are welcomed to apply. Research experience in mitochondrial biology or immunology is required. Experience or willingness to work with transgenic mouse colonies is highly desired but not required. Expertise in one or the more of following skills/techniques is highly desired:
Biochemical assays (immunoprecipitation, Chip), Immunofluorescence/immunohistochemistry, fluorescence or confocal imaging, mammalian cell culture, stem cell biology, molecular biology techniques, RNA and protein work, multicolor FACS analysis, mouse models of disease/autoimmunity, and prior experience on handling large data sets (RNAseq, proteomics).