Structural Biology

Structural biology explores the three-dimensional shapes of biological macromolecules and their complexes at atomic resolution. Approaches such as X-ray crystallography, nuclear magnetic resonance, solution X-ray scattering, and electron microscopy are used to determine the myriad physical forms that proteins and nucleic acids adopt. An understanding of these architectures allows researchers essential views into the molecular world that can explain how the cellular machinery works and drive new lines of experimentation. Structural studies in the department are facilitated by an impressive array of instrumentation both on campus and off, including the Nuclear Magnetic Resonance Facility at Madison (NMRFAM) and the Advanced Photon Source synchrotron located nearby in Argonne, Ill.

Relevant Labs: Brow, Chanda, Keck, Kiley, Mosher.

Davd Brow Head Shot

David A. Brow

Professor

(608)262-1475


Molecular machines of gene expression; RNA-based gene regulation.

Baron Chanda

Baron Chanda

Associate Professor

(608) 265-3936


Understanding the fundamental mechanisms that underlie gating and modulation of voltage-activated ion channels.

James L. Keck Headshot

James L. Keck

Professor; also Associate Dean for Basic Sciences, UW SMPH

(608) 263-1815


Structural mechanisms that drive DNA replication, replication restart, recombination, and repair reactions.

Tricia Kiley Headshot

Tricia Kiley

Professor and Chair

(608) 262-6632


Signaling pathways and gene expression programs used by organisms to respond to changes in the levels of oxygen in the environment.

Deane F. Mosher

Deane F. Mosher

Professor

(608) 262-1576


Cell Structure and Signaling
Molecular Medicine
Structural Biology