Membrane biology and cell signaling

The ability of cells to sense and react to their surroundings governs their capacity to proliferate, develop, differentiate, and maintain tissue homeostasis. Deficiencies in appropriately translating environmental cues underlie many forms of cancer, neurodegeneration, and immune dysfunction. Our faculty members study the mechanistic basis of signal transduction using a diverse array of models, including E. coli, pathogenic fungi, C. elegans, and mammalian cells. The critical signaling that occurs in response to external stimuli is often initiated at the surface of cells and traverses a network of membrane bound compartments, to ultimately elicit changes in cellular gene expression and metabolism. How these signaling pathways are effectively integrated to facilitate a defined cellular response is a major focus of our membrane biology and cell signaling faculty.

Relevant Labs: Audhya, Chanda, Engin, Merrins, Mosher.

Jon Audhya Head Shot

Jon Audhya

Associate Professor

(608) 262-3761


Understanding the fundamental mechanisms by which membrane proteins, lipids, and other macro molecules are transported throughout eukaryotic cells.

Baron Chanda

Baron Chanda

Associate Professor

(608) 265-3936


Understanding the fundamental mechanisms that underlie gating and modulation of voltage-activated ion channels.

Feyza Engin Headshot

Feyza Engin

Assistant Professor

(608) 262-8667


The role of organelle stress and adaptive responses in pathogenesis of metabolic and autoimmune disorders.

Matthew Merrins

Matthew J. Merrins

Assistant Professor

(608) 256-1901 x12848


Biomolecular Folding & Interactions
Membrane Dynamics & Proteins
Metabolism & Endocrinology

Deane F. Mosher

Deane F. Mosher

Professor

(608) 262-1576


Cell Structure and Signaling
Molecular Medicine
Structural Biology