Understanding the fundamental mechanisms by which membrane proteins, lipids, and other macro molecules are transported throughout eukaryotic cells.
Molecular machines of gene expression; RNA-based gene regulation.
Understanding the fundamental mechanisms that underlie gating and modulation of voltage-activated ion channels.
Bioanalytical Chemistry, Mass Spectrometry & Proteomics.
Mathematical and Computational Methods in Biology and Medicine.
Mechanism and biological function of reversible protein modifications involved in modulating signal transduction, metabolic regulation and chromatin dynamics.
Mechanisms of RNA splicing, and the role of mis-regulated RNA processing in cancer.
The role of organelle stress and adaptive responses in pathogenesis of metabolic and autoimmune disorders.
Mechanisms that regulate chromosome replication and genome stability.
Transcriptional mechanisms driving early embryonic development and the establishment of totipotency.
Transcriptional networks in fungal development; pathogenic spore biology and host-pathogen interactions.
Professor; also Associate Dean for Basic Sciences, UW SMPH
Structural mechanisms that drive DNA replication, replication restart, recombination, and repair reactions.
Signaling pathways and gene expression programs used by organisms to respond to changes in the levels of oxygen in the environment.
Epigenetic Mechanisms in Development and Cancer.
Cell Structure and Signaling
Post-transcriptional control of vertebrate development; Regulated mRNA translation as an important mechanism for the regulation of early cell-fate decisions in vertebrate embryos.
Biomolecular Folding & Interactions
Membrane Dynamics & Proteins
Metabolism & Endocrinology
Initiation and regulation of protease cascades, which govern a variety of essential physiological processes from blood clotting to mechanisms of cell death.