Computational and Systems Biology

Living systems are dynamic and complex, and their behavior may be hard to predict from the properties of individual parts. In particular, biochemical interaction networks may give rise to unexpected properties in the presence of complex interconnections and feedbacks between the genes, proteins, and metabolites involved in these networks. Computational and systems biology analyses biochemical systems (such as networks of metabolites, proteins and enzymes which comprise metabolism, signal transduction pathways and gene regulatory networks) by using genomics, proteomics, and metabolomics data together with computational and mathematical tools, in order to understand their emergent properties due to complex connections among different cellular processes.

Relevant Labs: Coon, Craciun, Dvinge, Fox, Harrison, Kiley, Mosher.

Joshua J. Coon Headshot

Joshua J. Coon

Professor

(608) 263-1718


Bioanalytical Chemistry, Mass Spectrometry & Proteomics.

Gheorghe Craciun

Gheorghe Craciun

Professor

(608) 265-3391


Mathematical and Computational Methods in Biology and Medicine.

heidi dvigne

Heidi Dvinge

Assistant Professor

(608) 265-1859

Mechanisms of  RNA splicing, and the role of mis-regulated RNA processing in cancer.

Catherine A. Fox

Catherine A. Fox

Professor

(608) 262-9370


Mechanisms that regulate chromosome replication and genome stability.

Melissa M. Harrison

Melissa M. Harrison

Assistant Professor

(608) 262-2382


Transcriptional mechanisms driving early embryonic development and the establishment of totipotency.

Tricia Kiley Headshot

Tricia Kiley

Professor and Chair

(608) 262-6632


Signaling pathways and gene expression programs used by organisms to respond to changes in the levels of oxygen in the environment.

Deane F. Mosher

Deane F. Mosher

Professor

(608) 262-1576


Cell Structure and Signaling
Molecular Medicine
Structural Biology