Chromosome Biology and Gene Expression

A mechanistic understanding of the interconnected roles that chromosome structure, chromatin and gene expression play in cell identity and proliferation is critical to multiple areas in basic biology and biomedicine. With the advances in next generation sequencing (NGS) and proteomics technologies, these fundamental issues can now be probed at a breadth and depth unimaginable even ten years ago. Several research programs in the department address important issues in chromosome structure, duplication and gene expression in a variety of model systems exploiting both cutting-edge NGS and proteomics approaches as well as classical microbiological, genetic, and molecular methods.

Relevant Labs: Brow, Hull, Kiley, Lewis, Fox, Denu, Keck, Harrison, Sheets

Davd Brow Head Shot

David A. Brow



Molecular machines of gene expression; RNA-based gene regulation.

John M. Denu Headshot

John M. Denu


(608) 265-1859

Mechanism and biological function of reversible protein modifications involved in modulating signal transduction, metabolic regulation and chromatin dynamics.

Catherine A. Fox

Catherine A. Fox


(608) 262-9370

Mechanisms that regulate chromosome replication and genome stability.

Melissa M. Harrison

Melissa M. Harrison

Assistant Professor

(608) 262-2382

Transcriptional mechanisms driving early embryonic development and the establishment of totipotency.

Christina M. Hull

Christina M. Hull

Associate Professor

(608) 265-5441

Transcriptional networks in fungal development; pathogenic spore biology and host-pathogen interactions.

James L. Keck Headshot

James L. Keck

Professor; also Associate Dean for Basic Sciences, UW SMPH

(608) 263-1815

Structural mechanisms that drive DNA replication, replication restart, recombination, and repair reactions.

Tricia Kiley Headshot

Tricia Kiley

Professor and Chair

(608) 262-6632

Signaling pathways and gene expression programs used by organisms to respond to changes in the levels of oxygen in the environment.

Peter W. Lewis Headshot

Peter W. Lewis

Assistant Professor

(608) 316-4388

Epigenetic Mechanisms in Development and Cancer.

Michael D. Sheets

Michael D. Sheets


(608) 262-9452

Post-transcriptional control of vertebrate development; Regulated mRNA translation as an important mechanism for the regulation of early cell-fate decisions in vertebrate embryos.