Chromosome Biology and Gene Expression
A mechanistic understanding of the interconnected roles that chromosome structure, chromatin and gene expression play in cell identity and proliferation is critical to multiple areas in basic biology and biomedicine. With the advances in next generation sequencing (NGS) and proteomics technologies, these fundamental issues can now be probed at a breadth and depth unimaginable even ten years ago. Several research programs in the department address important issues in chromosome structure, duplication and gene expression in a variety of model systems exploiting both cutting-edge NGS and proteomics approaches as well as classical microbiological, genetic, and molecular methods.
Relevant Labs: Brow, Dvinge, Hull, Kiley, Lewis, Fox, Denu, Keck, Harrison, Sheets
Molecular machines of gene expression; RNA-based gene regulation.
Mechanism and biological function of reversible protein modifications involved in modulating signal transduction, metabolic regulation and chromatin dynamics.
Mechanisms of RNA splicing, and the role of mis-regulated RNA processing in cancer.
Mechanisms that regulate chromosome replication and genome stability.
Transcriptional mechanisms driving early embryonic development and the establishment of totipotency.
Transcriptional networks in fungal development; pathogenic spore biology and host-pathogen interactions.
Professor; also Associate Dean for Basic Sciences, UW SMPH
Structural mechanisms that drive DNA replication, replication restart, recombination, and repair reactions.
Signaling pathways and gene expression programs used by organisms to respond to changes in the levels of oxygen in the environment.
Epigenetic Mechanisms in Development and Cancer.
Post-transcriptional control of vertebrate development; Regulated mRNA translation as an important mechanism for the regulation of early cell-fate decisions in vertebrate embryos.