The Fox Lab pursues structural and functional studies of eukaryotic chromosomes and associated regulatory proteins using the budding yeast Saccharomyces cerevisiae as a model organism.
Major Interests Include:
-DNA replication origins: selection and function within chromatin
-The origin recognition complex (ORC)
-Heterochromatin (silencing) and Silent Information Regulator (SIR) proteins
-Cell cycle regulators and chromatin dynamics