faculty navigation



Deane Mosher

deane mosher


5428A Biochemical Sciences Bldg.
440 Henry Mall
Madison WI 53706

Phone: (608) 262-4455
Fax: (608) 263-4969


The Mosher Lab


  • M.D. 1968, Harvard Medical School
  • Postdoctoral 1970-72, Harvard Medical School (Elkan Blout).

Honors & Awards

  • 1997 - R.F. Schilling WARF Professor
  • 1982-87 - H.I. Rommes Fellow

Research Interests

Publications of Note

Perform a customized PubMed literature search for Dr. Mosher.

  1. Annis DS, Gunderson KA, Mosher DF. Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations. Papers In Press. J. Biol. Chem., Jul 2007;
  2. Barthel SR, Annis DS, Mosher DF, Johansson MW. Differential engagement of modules 1 and 4 of VCAM-1 (CD106) by integrins alpha4 beta1 (CD49d/29) and alphaM beta2 (CD11b/18) of eosinophils. J Biol Chem 281:32175-87, 2006.
  3. Cho J, Mosher DF. Impact of fibronectin assembly on platelet thrombus formation in response to type I collagen and von Willebrand factor. Blood, 108:2229-36, 2006
  4. Barthel SR, Jarjour NN, Mosher DF, Johansson MW. Dissection of the hyper-adhesive phenotype of airway eosinophils in asthma. Am J Resp Cell Mol Biol 35:378-86, 2006.
  5. Barthel SR, Johansson MW, Annis DS, Mosher DF. Cleavage of human 7-domain VCAM-1 (CD106) by thrombin. Thromb Haemost 95:873-80, 2006.
  6. Johansson MW, Barthel SR, Swenson CA, Evans MD, Jarjour NN, Mosher DF, Busse WW. Eosinophil b1 integrin activation state correlates with asthma activity in a blinded study of inhaled corticosteroid withdrawal. J Allergy Clin Immunol 117:1502-4, 2006.
  7. Cho J, Mosher DF. Characterization of fibronectin assembly by platelets adherent to adsorbed laminin-111. J Thromb Haemost 4:943-51, 2006.
  8. Tomasini-Johansson BR, Annis DS, Mosher DF. The N-terminal 70-kDa fragment of fibronectin binds to cell surface fibronectin assembly sites in the absence of intact fibronectin. Matrix Biol 25:282-93, 2006.
  9. Cho J, Mosher DF. Enhancement of thrombogenesis by plasma fibronectin crosslinked to fibrin and assembled in platelet thrombi. Blood 107:3555-63, 2006
  10. Annis DS, Murphy-Ullrich JE, Mosher DF. Function-blocking anti-thrombospondin-1 monoclonal antibodies. J Thromb Haemost, 4:459-68, 2006.
  11. Misenheimer T, Mosher DF. Biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2. J Biol Chem, 280:41229-35, 2005.
  12. Carlson CB, Bernstein DA, Annis DS, Misenheimer TM, Hannah BL, Mosher DF, Keck JL. Structure of the calcium-rich signature domain of human thrombospondin-2. Nat Struct Mol Biol 12:910-4, 2005.
  13. Cho J, Degen JL, Coller BS, Mosher DF. Fibrin but not absorbed fibrinogen supports fibronectin assembly by spread platelets: effects of the interaction of aIIbb3 with the C-terminus of the fibrinogen g-chain. J Biol Chem, 280:35490-8, 2005.
  14. Hannah BL, Misenheimer TM, Pranghofer MM, Mosher DF. A polymorphism in thrombospondin-1 associated with familial premature coronary artery disease alters Ca2+ binding. J Biol Chem 279:51915 - 22, 2004.
  15. Calzada MJ, Annis DS, Zeng B, Marcinkiewicz C, Banas B, Lawler J, Mosher DF, Roberts DD. Identification of novel beta-1 integrin binding sites in the type 1 and type 2 repeats of thrombospondin-1 J Biol Chem 279: 41734-43, 2004.
  16. Ensenberger MG, Annis DS, Mosher DF. Actions of the functional upstream domain of protein F1 of Streptococcus pyogenes on the conformation of fibronectin Biophys Chem 112:201-7, 2004.
  17. Johansson MW, Lye MH, Barthel SR, Duffy AK, Annis DS, Mosher DF. Eosinophils adhere to VCAM-1 via podosomes. Am J Resp Cell Mol Biol 31: 413-22, 2004.
  18. Bae E, Sakai T, Mosher DF. Assembly of exogenous fibronectin by fibronectin-null cells is dependent on the adhesive substrate. J Biol Chem 279:35749-59, 2004.
  19. Huwiler KG, Mosher DF, Vestling MM. Optimizing the MALDI-TOF-MS observation of peptides containing disulfide bonds. J Biomolecular Techniques 14:289-97, 2003.
  20. Misenheimer TM, Hannah BL, Annis DS, Mosher DF. Interactions among the three structural motifs of the C- terminal region of human thrombospondin-2. Biochemistry 42:5125-32, 2003.
  21. Hannah BL, Misenheimer TM, Annis DS, Mosher DF. A Polymorphism in thrombospondin-1 associated with familial premature coronary heart disease causes a local change in conformation of the Ca++ binding repeats. J Biol Chem 278: 8929-34, 2003.




University of Wisconsin - Department of Biomolecular Chemistry
First published: 01/01/05 Last updated: 08/15/07 Email Biomolecular Chemistry
Copyright © 2007 The Board of Regents of the University of Wisconsin System


biomolecular chemistry home joshua coon graduate program department faculty jon audhya david brow george craciun james dahlberg john denu robert fillingame catherine fox christina hull christina hull james keck deane mosher bmc courses events calendar department info contact info tricia kiley michael sheetsMatthew Merrins Feyza Engin uw madison homepage