Patricia J. Kiley
Honors & Awards
We are interested in the signaling pathways and gene expression programs
organisms use to respond to changes in the levels of oxygen in the
environment. Oxygen is essential for life of aerobic organisms but can also
act as a poison by causing oxidative damage to proteins, lipids and DNA.
Therefore, an organism’s ability to respond efficiently and precisely
to oxygen is critical to its survival.
Publications of Note
Giel, J.L., D. Rodionov, M. Liu, F. R. Blattner, and P. J. Kiley. 2006. IscR-dependent gene expression links iron-sulfur cluster assembly to the control of O2-regulated genes in Escherichia coli. Mol. Microbiol. 4:1058-1075.
Mettert, E, and P. J. Kiley. 2005. ClpXP-dependent proteolysis of FNR upon loss of its O2-sensing [4Fe-4S] cluster. J. Mol. Biol. 354:220-232.
Kang, Y., K. Derek Weber, Y. Qiu, P.J. Kiley and F. R. Blattner. 2005. Genome wide expression analysis indicates that FNR of Escherichia coli K12 regulates a large number of genes of unknown function. J. Bacteriol. 187:1135-1160
Sutton, V.R, T. Patschkowski, and P.J. Kiley. 2004. Superoxide destroys the [2Fe-2S]2+ cluster of FNR from Escherichia coli. Biochemistry. 43:791-798.
Sutton, V. R., E. L. Mettert, H. Beinert, and P.J. Kiley. 2004. Kinetic analysis of the oxidative conversion of the [4Fe-4S]2+ cluster of FNR to a [2Fe-2S]2+ cluster. J. Bacteriol 186: 8018-8025.
Lamberg, K. E., C. Luther, K.D. Weber and P.J. Kiley. 2002. Characterization of activating region 3 from Escherichia coli. J. Mol. Biol. 315:275-283.
Moore, L. and P.J. Kiley. 2001. Characterization of the dimerization domain in the FNR transcription factor. J. Biol. Chem. 276: 45744-45750.
Schwartz, C. J., J. L. Giel, T. Patschkowski, C. Luther, F. J. Ruzicka, H. Beinert and P. J. Kiley. 2001. IscR, an Fe-S cluster containing transcription factor, represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins. PNAS 98: 14895-14900.
Kiley P.J. and G. Storz. 2004. Exploiting thiol modifications. PLOS Biology 2:1714-1717.
Kiley, P. J. and H. Beinert. 2003. Role of Fe-S clusters in sensing and regulating bacterial growth. Current Opinion in Microbiology. 6:181-185.
Sutton, V.R., and P.J. Kiley. 2003 Anaerobic isolation and assays for the transcription factor FNR from Escherichia coli. Methods in Enzymology. 370: 300-12.
Patschowski, T., D. M. Bates and P. J. Kiley. 2000. Mechanism for sensing and responding to oxygen deprivation in prokaryotic organisms. "Bacterial Stress Responses" ASM Press Washington, D. C. p. 61- 78.
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of Wisconsin - Department
of Biomolecular Chemistry