- B.S. 1997, Brown University, Providence, RI;
- Ph.D. 2002, University of California, San Diego (S. Emr);
- Postdoctoral 2003-07, Ludwig Institute for Cancer Research (K. Oegema).
Honors & Awards
- March of Dimes Basil O'Connor Starter Scholar Award, 2010.
- American Heart Association SDG Award, 2010.
- Shaw Scientist Award, 2010.
- Helen Hay Whitney Foundation Fellowship, 2004-2007.
- DeLill Nasser Award for Professional Development in Genetics, 2006.
Our laboratory is committed to understanding the fundamental mechanisms by which membrane proteins, lipids, and other macromolecules are transported throughout eukaryotic cells. To do so, we take advantage of numerous interdisciplinary approaches, including biochemistry, structural biology, biophysics, genetics, molecular biology and high-resolution fluorescence and electron microscopy.
Additionally, we use a variety of experimental systems, ranging from simple animal models (e.g. Caenorhabditis elegans) to human induced pluripotent stem cells (iPSCs). We also aim to recapitulate individual steps of membrane transport in vitro, using recombinant proteins and chemically defined lipids. Our ultimate goal is to identify the regulatory pathways that control membrane deformation, which enable vesicle formation in the endosomal and secretory systems. Although basic research is the cornerstone of our program, we also seek to define pathomechanisms that underlie human disease, focusing on the impact of mutations in key trafficking components that lead to cancer, neurodegeneration, asthma, and diabetes. For more information, please visit our lab webpage: www.audhyalab.org.
Publications of Note
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- Shi, A., Chen, C.C., Banerjee, R., Glodowski, D., Audhya, A., Rongo, C., and Grant, B.D. (2010). EHBP-1 functions with RAB-10 during endocytic recycling in C. elegans. Mol. Biol. Cell. In press.
- Ziel, J.W., Hagedorn, E.J., Audhya, A., and Sherwood, D.R. (2009). UNC-6 (Netrin) orients the invasive membrane of the anchor cell in C. elegans. Nat. Cell Biol. 11: 183-189.
Audhya, A., and Desai, A. (2008). Proteomics in Caenorhabditis elegans. Brief. Funct. Genomic. Proteomic. 7: 205-210.
Audhya, A., McLeod, I.X., Yates, J.R. III, and Oegema, K. (2007). MVB-12, a Fourth Subunit of Metazoan ESCRT-I, Functions in Receptor Downregulation. PLoS ONE. 2: e956.
- Audhya, A., Desai, A., and Oegema, K. (2007). A role for Rab5 in ER structure and nuclear envelope disassembly. J. Cell Biol. 178: 43-56.
- Portier, N., Audhya, A., Maddox, P.S., Green, R.A., Dammermann, A., Desai, A., and Oegema, K. (2007). A microtubule-independent role for centrosomes and Aurora A in nuclear envelope breakdown. Dev. Cell. 12: 515-529.
- McNally, K., Audhya, A., Oegema, K., and McNally, F.J. (2006). Katanin controls mitotic and meiotic spindle length. J. Cell Biol. 175: 881-891.
- Sato, K., Sato M., Audhya, A., Oegema, K., Schweinsberg, P., and Grant, B.D. (2006). Dynamic regulation of Caveolin-1 trafficking in the germ line and embryo of Caenorhabditis elegans. Mol. Biol. Cell. 17: 3085-3094.
- Grant, B.D., and Audhya, A. (2005). The ins and outs of endocytic transport. Nat. Cell Biol. 7: 1051-1054.
- Audhya, A., Hyndman, F., McLeod, I.X., Maddox, A.S., Yates, J.R. III, Desai, A., and Oegema, K. (2005). A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans. J. Cell Biol. 171: 267-279.
- Sciorra, V.A., Audhya, A., Parsons, A.B., Segev, N., Boone, C., and Emr, S.D. (2005). Synthetic genetic array analysis of the PtdIns 4-kinase Pik1p identifies components in a Golgi-specific Ypt31/rab-GTPase signaling pathway. Mol. Biol. Cell. 16: 776-793.
- Audhya, A., Loewith, R., Parsons, A.B., Gao, L., Tabuchi, M., Zhao, H., Boone, C., Hall, M.N., and Emr, S.D. (2004). Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. EMBO J. 23: 3747-3757.
- Yu, J.W., Mendrola, J.M., Audhya, A., Keleti, D., Dewald, D., Emr, S.D., and Lemmon, M.A. (2004). Genome-wide analysis of PH domain function in Saccharomyces cerevisiae. Mol. Cell. 13: 677-688.
- Katzmann, D.J., Sarkar, S., Chu, T., Audhya, A., and Emr, S.D. (2004). Multivesicular Body Sorting: Ubiquitin ligase Rsp5 is required for the modification and sorting of Carboxypeptidase S. Mol. Biol. Cell. 15: 468-480.
- Audhya, A., and Emr, S.D. (2003). Regulation of PI4,5P2 synthesis by nuclear-cytoplasmic shuttling of the Mss4 lipid kinase. EMBO J. 22: 4223-4236.
- Odorizzi, G., Katzmann, D.J., Babst, M., Audhya, A., and Emr, S.D. (2003). Bro1 is an endosome-associated class E Vps protein that functions in the MVB-sorting pathway in Saccharomyces cerevisiae. J. Cell Sci. 115: 1893-1903.
- Audhya, A., and Emr, S.D. (2002). Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. Dev. Cell 2: 593-605.
of Wisconsin - Department
of Biomolecular Chemistry
15 July 2010 Email Biomolecular Chemistry
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